Description

4-[(2,2,2-Trifluoroethoxy)Methyl]Benzoic Acid is a high-value fluorinated aromatic building block, distinguished by its trifluoroethoxymethyl side chain. This structural motif is critical for modulating the physicochemical properties of target molecules, particularly enhancing metabolic stability and lipophilicity. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) agents, anti-inflammatory drugs, and oncology therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor for fluorinated liquid crystal compounds used in high-performance displays (LCDs).
• Polymer Chemistry: Employed as a monomer or modifier to introduce fluorine into polymer backbones, enhancing chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, esterifications, and amide couplings to create complex, fluorinated organic molecules for material science and chemical biology.
• Advanced Material Research: Investigated for use in the development of organic semiconductors, photovoltaic materials, and specialty coatings.

Basic Information

Product Name	4-[(2,2,2-Trifluoroethoxy)Methyl]Benzoic Acid
CAS No.	438473-98-4
Molecular Formula	C10H9F3O3
Molecular Weight	234.17 g/mol
Synonyms	4-[(2,2,2-Trifluoroethoxy)methyl]benzoic acid; Benzoic acid, 4-[(2,2,2-trifluoroethoxy)methyl]-; 4-(2,2,2-Trifluoroethoxymethyl)benzoic acid; 4-(Trifluoroethoxymethyl)benzoic acid; 4-Carboxybenzyl 2,2,2-trifluoroethyl ether; p-[(2,2,2-Trifluoroethoxy)methyl]benzoic acid; 438473-98-4
EINECS	Contact for details

Quality Control

Our 4-[(2,2,2-Trifluoroethoxy)Methyl]Benzoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and strong reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.