Description

Semagacestat CAS NO 425386-60-3 is a potent and selective γ-secretase inhibitor. This compound is of significant interest in pharmaceutical research and development, particularly for investigating pathways related to amyloid precursor protein (APP) processing. It serves as a critical research tool for scientists and organizations focused on neurodegenerative diseases, oncology, and cell signaling mechanisms.

Application

• Pharmaceutical Research & Development: A key reference standard and active compound in the study of γ-secretase inhibition for potential therapeutic applications.
• Neurodegenerative Disease Studies: Used extensively in preclinical research models for Alzheimer's disease to investigate the modulation of amyloid-beta peptide production.
• Oncology Research: Employed in cancer research to study the role of Notch signaling pathways in tumorigenesis and as a potential chemotherapeutic agent.
• Biochemical Assay Development: Serves as a critical component in developing and validating high-throughput screening assays for γ-secretase activity.
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental studies in cell biology, proteolysis, and signal transduction.
• Contract Research Organizations (CROs): Supplied to CROs conducting client-sponsored research on targeted therapies and drug discovery programs.

Basic Information

Product Name	Semagacestat
CAS No.	425386-60-3
Molecular Formula	C21H23F2N3O4
Molecular Weight	419.42 g/mol
Synonyms	LY450139; (2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl]amino]ethyl]butanamide; γ-secretase inhibitor LY450139; N1-[(2S)-2-Hydroxy-3-methylbutanoyl]-L-alanyl-L-tryptophanamide; UNII-6I9K30534M
EINECS	Contact for details

Quality Control

Our Semagacestat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.