Description

Pramipexole CAS NO 404875-32-7 is a high-purity, non-ergoline dopamine agonist of significant pharmaceutical importance. It is a critical active pharmaceutical ingredient (API) primarily used in the treatment of Parkinson's disease and Restless Legs Syndrome (RLS). This compound is essential for pharmaceutical manufacturers and research institutions developing neurological therapeutics. We supply it under stringent quality control to ensure reliability for formulation and clinical research.

Application

• Primary Pharmaceutical Ingredient: Core API in the manufacture of finished dosage forms for Parkinson's disease treatment.
• Neurological Disorder Therapy: Formulation into tablets for managing symptoms of Restless Legs Syndrome (RLS).
• Clinical Research & Development: Used as a reference standard and active component in preclinical and clinical studies for new neurological drugs.
• Generic Drug Manufacturing: Sourcing for the production of bioequivalent generic versions of branded pramipexole medications.
• Pharmacological Studies: Utilized in laboratory research to investigate dopamine receptor mechanisms and related pathways.

Basic Information

Product Name	Pramipexole
CAS No.	404875-32-7
Molecular Formula	C10H17N3O·2HCl
Molecular Weight	284.18 g/mol (as dihydrochloride monohydrate)
Synonyms	Pramipexole Dihydrochloride; SND 919; SND-919; 2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole Dihydrochloride; (S)-(-)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole Dihydrochloride; Mirapex (brand name active); Mirapexin (brand name active)
EINECS	Contact for details

Quality Control

Our Pramipexole Dihydrochloride is manufactured and tested to meet the highest pharmacopeial standards, including USP and EP monographs. Every batch undergoes rigorous analytical testing for identity, purity, potency, and impurity profiles (including related substances and residual solvents). A comprehensive Certificate of Analysis (COA) is provided with each shipment, ensuring full traceability and compliance with cGMP guidelines for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.15% Total impurities: ≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Specific Rotation	-82.0° to -86.0° (c = 1 in water)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.