Description

2-Thiophenecarboxamide,n-(3R)-1-Azabicyclo[2.2.2]Oct-3-Yl-5-Methyl-(9Ci) is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and heterocyclic structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting neurological and other therapeutic areas. It is primarily sought after by pharmaceutical companies, biotechnology research firms, and academic institutions engaged in drug discovery programs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug candidates, especially those targeting the central nervous system.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Neurological Drug Development: Serves as a precursor for compounds interacting with specific neurotransmitter receptors.
• Chemical Biology Probes: Utilized in the development of selective molecular probes for studying biological pathways.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for cGMP-scale production of clinical trial materials.
• Academic & Institutional Research: Used in university and government labs for fundamental pharmacological and synthetic chemistry research.

Basic Information

Product Name	2-Thiophenecarboxamide,n-(3R)-1-Azabicyclo[2.2.2]Oct-3-Yl-5-Methyl-(9Ci)
CAS No.	400713-46-4
Molecular Formula	C13H18N2OS
Molecular Weight	250.36 g/mol
Synonyms	5-Methyl-2-thiophenecarboxamide, N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-; (R)-N-(Quinuclidin-3-yl)-5-methylthiophene-2-carboxamide; 3-[(5-Methyl-2-thienyl)carbonyl]aminoquinuclidine; (3R)-3-[(5-Methyl-2-thiophenecarbonyl)amino]quinuclidine; TC-2559 (developmental code); A-366833 (developmental code); 400713-46-4; N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]-5-methyl-2-thiophenecarboxamide
EINECS	Contact for details

Quality Control

Our production of 2-Thiophenecarboxamide,n-(3R)-1-Azabicyclo[2.2.2]Oct-3-Yl-5-Methyl-(9Ci) adheres to stringent quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development under quality agreements and can supply material suitable for use in cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (R-isomer)
Related Substances (HPLC)	Any single impurity ≤0.5%; Total impurities ≤1.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.