Description

6-β-Naltrexol Hcl is a high-purity pharmaceutical reference standard and key intermediate used in advanced research and development. This compound is critical for analytical method development, metabolite studies, and the synthesis of novel therapeutic agents targeting opioid receptors. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on neuropharmacology and analytical chemistry.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for the identification and quantification of naltrexone and its metabolites in analytical methods (e.g., HPLC, LC-MS).
• Metabolite Research: Serves as a critical metabolite of naltrexone for pharmacokinetic and pharmacodynamic studies in drug development.
• Active Pharmaceutical Ingredient (API) Intermediate: Employed in the synthesis and scale-up of opioid antagonist drugs and related pharmaceutical compounds.
• Biochemical Research: Used in in vitro and in vivo studies to investigate opioid receptor binding, antagonism, and signal transduction pathways.
• Forensic Toxicology: Acts as a calibrant or control in forensic analyses for detecting and confirming opioid treatment regimens.
• Quality Control (QC) Testing: Essential for the internal QC of pharmaceutical manufacturers producing naltrexone-based medications.

Basic Information

Product Name	6-β-Naltrexol Hcl
CAS No.	49625-89-0
Molecular Formula	C20H24ClNO4
Molecular Weight	377.86 g/mol
Synonyms	6β-Naltrexol Hydrochloride; 6β-Naltrexol HCl; 17-(Cyclopropylmethyl)-4,5α-epoxy-3,14-dihydroxymorphinan-6β-ol Hydrochloride; 6β-Hydroxynaltrexone Hydrochloride; 6β-Naltrexol Monohydrochloride; Noroxymorphone-6β-ol Cyclopropylmethyl Ether Hydrochloride; BNTX Hcl
EINECS	Contact for details

Quality Control

Our 6-β-Naltrexol Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development purposes. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.