Description

(+)-5,6,7,9,10,14B-Hexahydro-2-Chloro-5-Methylisoquino[2,1-D][1,4]Benzodiazepine is a high-purity, chiral benzodiazepine derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or reference standard for the creation of novel therapeutic agents targeting the central nervous system. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing new drug candidates, particularly in the areas of neurology and psychiatry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel benzodiazepine-based active pharmaceutical ingredients (APIs).
• Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Medicinal Chemistry Research: A crucial scaffold for structure-activity relationship (SAR) studies to explore new therapeutic pathways.
• Preclinical Studies: Employed in the development and testing of new drug candidates in laboratory settings.
• Fine Chemical Synthesis: Serves as a specialized intermediate for the production of complex, high-value organic molecules.

Basic Information

Product Name	(+)-5,6,7,9,10,14B-Hexahydro-2-Chloro-5-Methylisoquino[2,1-D][1,4]Benzodiazepine
CAS No.	48187-65-1
Molecular Formula	C19H19ClN2
Molecular Weight	310.82 g/mol
Synonyms	(+)-2-Chloro-5-methyl-5,6,7,9,10,14b-hexahydroisoquino[2,1-d][1,4]benzodiazepine; (6aS,14bR)-2-Chloro-5-methyl-5,6,6a,7,9,10,14,14b-octahydroisoquino[2,1-d][1,4]benzodiazepine; (6aS,14bR)-2-Chloro-5-methyl-5,6,6a,7,9,10,14,14b-octahydroisoquino[2,1-d][1,4]benzodiazepin; (6aS,14bR)-2-Chloro-5-methyl-5,6,6a,7,9,10,14,14b-octahydroisoquino[2,1-d]pyrido[2,3-f][1,4]diazepine; (6aS,14bR)-2-Chloro-5-methyl-5,6,6a,7,9,10,14,14b-octahydroisoquino[2,1-d][1,4]benzodiazepine; CAS 48187-65-1
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Quality Control

Our (+)-5,6,7,9,10,14B-Hexahydro-2-Chloro-5-Methylisoquino[2,1-D][1,4]Benzodiazepine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and structural confirmation, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.