Description

4-Thia-1-Azabicyclo(3.2.0)Heptane-2-Carboxylic Acid, 3,3-Dimethyl-7-Oxo-6-(((Tetrahydro-5-Methyl-2-Furanyl)Carbonyl)Amino)-, (2S-(2-Alpha,5-Alpha,6-Beta))- is a key advanced pharmaceutical intermediate with a complex bicyclic β-lactam structure. This compound is critical for the synthesis of specific carbapenem-class antibiotics, offering a high-purity building block for complex molecular construction. It is primarily required by pharmaceutical R&D laboratories and active pharmaceutical ingredient (API) manufacturers focused on developing and producing next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of potent carbapenem antibiotics.
• Antibacterial API Development: Used in research and development for creating novel broad-spectrum antibacterial agents to combat resistant infections.
• Chemical Synthesis Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry & Scale-Up: Utilized in optimizing and scaling manufacturing routes for complex β-lactam-based pharmaceuticals.
• Academic & Institutional Research: Supports studies in medicinal chemistry, particularly in the field of β-lactamase inhibitor design and antibiotic resistance mechanisms.

Basic Information

Product Name	4-Thia-1-Azabicyclo(3.2.0)Heptane-2-Carboxylic Acid, 3,3-Dimethyl-7-Oxo-6-(((Tetrahydro-5-Methyl-2-Furanyl)Carbonyl)Amino)-, (2S-(2-Alpha,5-Alpha,6-Beta))-
CAS No.	47219-50-1
Molecular Formula	C14H20N2O5S
Molecular Weight	328.38 g/mol
Synonyms	(2S,5R,6S)-6-[(2R)-2-[(Tetrahydro-5-methyl-2-furanyl)carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6-[(Tetrahydro-5-methyl-2-furoyl)amino]penicillanic acid derivative; Carbapenem intermediate; PNU-100592 intermediate; Faropenem related compound; (5R,6S)-2-Carboxy-3,3-dimethyl-7-oxo-6-[(tetrahydro-5-methyl-2-furoyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical pharmaceutical synthesis. The material is typically supplied at high purity grades suitable for API manufacturing, with specifications aligned with ICH guidelines. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.