Description

5-Fluorodopa is a fluorinated analog of the amino acid L-DOPA, a critical precursor in neurotransmitter synthesis. This compound is primarily valued as a key intermediate and research chemical in the development of novel radiopharmaceuticals and neurochemical probes. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic imaging sectors, particularly those focused on positron emission tomography (PET) and the study of dopaminergic systems.

Application

• PET Radiopharmaceutical Precursor: Serves as a crucial starting material for the synthesis of [18F]5-Fluorodopa, a diagnostic tracer used in PET imaging for neurological disorders.
• Neurochemical Research: Used as a biochemical tool to study dopamine metabolism, enzyme kinetics (e.g., aromatic L-amino acid decarboxylase), and blood-brain barrier transport mechanisms.
• Pharmaceutical Intermediate: Acts as a building block in the research and development of new therapeutic agents targeting Parkinson's disease and related central nervous system conditions.
• Isotope Labeling Studies: Employed in metabolic pathway tracing and pharmacokinetic studies due to the presence of the fluorine atom, which can be replaced with radioactive fluorine-18.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and validation in pharmaceutical analysis.

Basic Information

Product Name	5-Fluorodopa
CAS No.	42877-15-6
Molecular Formula	C9H10FNO4
Molecular Weight	215.18 g/mol
Synonyms	5-Fluoro-L-dopa; 5-FDOPA; (2S)-2-Amino-3-(5-fluoro-2,4-dihydroxyphenyl)propanoic acid; 5-Fluoro-3,4-dihydroxy-L-phenylalanine; 5-Fluorolevodopa; L-5-Fluorodopa; 5-Fluoro-DL-dopa (racemic mixture); 5-Fluorodihydroxyphenylalanine
EINECS	Contact for details

Quality Control

Our 5-Fluorodopa is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets high-grade research and pharmaceutical intermediate standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider conditions under an inert atmosphere to prevent potential oxidation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.