Description

Dansyl-L-Proline is a high-purity, fluorescent-labeled derivative of the amino acid L-proline, widely recognized under CAS number 42808-11-7. This compound serves as a critical reagent in advanced biochemical research and analytical method development due to its excellent fluorescence properties. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and diagnostic kit manufacturers for applications requiring sensitive detection and quantification.

Application

• Fluorescent Labeling Agent: Used for the pre-column or post-column derivatization of amino acids, peptides, and proteins for enhanced detection in chromatographic analyses (HPLC, UPLC).
• Biochemical Research: Acts as a substrate or probe in enzyme kinetics studies, particularly for proline-specific enzymes like prolyl oligopeptidase or proline dehydrogenases.
• Pharmaceutical Analysis: Employed in the development and validation of analytical methods for the quantification of proline and related compounds in drug substances and formulations.
• Proteomics & Metabolomics: Facilitates the sensitive detection and profiling of proline-containing metabolites in complex biological samples.
• Diagnostic Assay Development: Incorporated into fluorescent assays and kits for clinical diagnostics and life science research.
• Quality Control Reference Standard: Serves as a certified reference material (CRM) for calibrating instruments and ensuring accuracy in analytical laboratories.

Basic Information

Product Name	Dansyl-L-Proline
CAS No.	42808-11-7
Molecular Formula	C₁₇H₂₂N₂O₄S
Molecular Weight	350.43 g/mol
Synonyms	5-(Dimethylamino)naphthalene-1-sulfonyl-L-proline; L-Proline, 5-(dimethylamino)-1-naphthalenesulfonyl-; DNS-L-Proline; Dansyl-L-proline; 1-Dimethylaminonaphthalene-5-sulfonyl-L-proline; N-Dansyl-L-proline; N-(5-Dimethylaminonaphthalene-1-sulfonyl)-L-proline
EINECS	Contact for details

Quality Control

Our Dansyl-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, spectroscopic identification (IR, NMR), and specific optical rotation verification, to ensure it meets the high standards required for research and analytical applications. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder or crystalline solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Specific Optical Rotation [α]²⁰D	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.