Description

2,5-Bis(Trifluoromethyl)Benzoic Acid is a high-value fluorinated aromatic building block characterized by its two electron-withdrawing trifluoromethyl groups. This structure is critical for modifying the physicochemical properties of target molecules, enhancing their metabolic stability, lipophilicity, and bioavailability. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, where the introduction of fluorine atoms is a key strategy in modern molecular design.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the CF3 groups contribute to improved pest selectivity and environmental persistence.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorine-containing compounds used in electronic displays and organic light-emitting diodes (OLEDs) due to its influence on electronic properties.
• Polymer & Material Science: Incorporated into specialty polymers and coatings to enhance chemical resistance, thermal stability, and surface properties.
• Organic Synthesis & Catalysis: Employed as a versatile reagent in cross-coupling reactions and as a ligand precursor in organometallic catalysis.
• Research & Development: A valuable compound for academic and industrial R&D focused on fluorochemistry and the exploration of new chemical entities.

Basic Information

Product Name	2,5-Bis(Trifluoromethyl)Benzoic Acid
CAS No.	42580-42-7
Molecular Formula	C9H4F6O2
Molecular Weight	258.12 g/mol
Synonyms	2,5-Bis(trifluoromethyl)benzoic acid; Benzoic acid, 2,5-bis(trifluoromethyl)-; α,α,α,α',α',α'-Hexafluoro-2,5-dimethylbenzoic acid; 2,5-Di(trifluoromethyl)benzoic acid; 2,5-Bis(trifluoromethyl)benzenecarboxylic acid; 2,5-Bistrifluoromethylbenzoic acid; 2,5-BTFA
EINECS	Contact for details

Quality Control

Our 2,5-Bis(Trifluoromethyl)Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	142 - 146 °C
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.