Description

Dibutyrylapomorphine is a chemically modified derivative of the potent dopamine agonist apomorphine, designed for enhanced stability and research utility. This compound is of significant interest in advanced pharmacological and neuroscience research due to its potential for improved pharmacokinetic properties. It serves as a critical reference standard and intermediate for researchers in pharmaceutical development, particularly those investigating treatments for Parkinson's disease and other central nervous system disorders.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified material for analytical method development, validation, and quality control in drug discovery and manufacturing.
• Neuroscience Research: A key tool compound for studying dopamine receptor (D1 and D2) pharmacology, signal transduction pathways, and neuronal activity in vitro and in vivo models.
• Metabolic Studies: Employed in research to investigate the metabolism, stability, and prodrug characteristics of apomorphine derivatives.
• Biochemical Assay Development: Serves as a ligand in receptor binding assays and functional screens to identify and characterize new therapeutic agents.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies on motor control, reward systems, and neurodegenerative diseases.
• Process Chemistry & Synthesis: Acts as a specialized intermediate for the synthesis of novel analogs in medicinal chemistry programs.

Basic Information

Product Name	Dibutyrylapomorphine
CAS No.	42390-72-7
Molecular Formula	C28H33NO5
Molecular Weight	463.57 g/mol
Synonyms	Apomorphine Dibutyrate; 10,11-Dihydroxyaporphine-6,6a-diol Di-2-methylpropanoate; 6aβ-Aporphine-10,11-diol, 6-(2-Methyl-1-oxopropoxy)-, (5α,6aα)-; Dibutyryl Apomorphine; Apomorphine Diisobutyrate; 6aβ-Aporphine-10,11-diol 6-(2-methylpropanoate)
EINECS	Contact for details

Quality Control

Our Dibutyrylapomorphine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming batch-specific results and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.