Description

3-[(1-Methylhexyl)Oxyiminomethyl]Rifamycin Sv is a chemically modified derivative of the potent ansamycin antibiotic, rifamycin SV, designed to enhance its pharmacological profile. This semi-synthetic compound is of significant interest for its potential to improve stability, bioavailability, and targeted activity against resistant bacterial strains. It serves as a critical intermediate and active pharmaceutical ingredient (API) for research and development in the pharmaceutical and biotechnology sectors, particularly for advancing next-generation anti-tuberculosis and antibacterial therapies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel rifamycin-class antibiotics aimed at overcoming bacterial resistance.
• Antibacterial Research: Used in microbiological and pharmacological studies to evaluate efficacy against Gram-positive bacteria, mycobacteria (including *Mycobacterium tuberculosis*), and other pathogens.
• API Development: Employed in the formulation development of new dosage forms, such as injectables or oral formulations, requiring enhanced drug delivery properties.
• Mechanism of Action Studies: Utilized in biochemical assays to study the inhibition of bacterial DNA-dependent RNA polymerase.
• Reference Standard: Acts as a high-purity chemical reference standard for quality control and analytical method development in regulatory submissions.

Basic Information

Product Name	3-[(1-Methylhexyl)Oxyiminomethyl]Rifamycin Sv
CAS No.	41776-73-2
Molecular Formula	C39H53N3O12
Molecular Weight	755.85 g/mol
Synonyms	Rifamycin SV, 3-[(1-Methylhexyl)oximinomethyl] derivative; Rifamycin SV 1-Methylhexyloxime; 3-Formylrifamycin SV O-(1-Methylhexyl)oxime; Rifamycin SV oxime derivative; Antibiotic AF/ABD; (3E)-3-{[(1-Methylhexyl)oxy]iminomethyl}rifamycin SV; Rifamycin SV methylhexyloxime
EINECS	Contact for details

Quality Control

Our 3-[(1-Methylhexyl)Oxyiminomethyl]Rifamycin Sv is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC, to ensure it meets high-grade pharmaceutical standards. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light). For long-term storage, consider conditions of 2-8°C. Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	Orange-red to brownish-red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single impurity ≤ 2.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.