Description

3-[(2-Propynyl)Oxyiminomethyl]Rifamycin Sv is a chemically modified derivative of the potent ansamycin antibiotic rifamycin SV, designed to enhance its pharmacological profile and stability. This semi-synthetic compound is of significant interest in pharmaceutical research and development for creating next-generation antibacterial agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and synthesis of novel anti-infective drugs targeting resistant bacterial strains.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced rifamycin analogs and prodrugs with improved efficacy.
• Antibacterial Research: Serves as a core structure for investigating structure-activity relationships (SAR) against Gram-positive bacteria and Mycobacterium tuberculosis.
• Prodrug Development: The propargyl oxyiminomethyl moiety can be leveraged in the design of targeted drug delivery systems.
• Biochemical Studies: Used as a tool compound to study bacterial RNA polymerase inhibition mechanisms.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	3-[(2-Propynyl)Oxyiminomethyl]Rifamycin Sv
CAS No.	41776-64-1
Molecular Formula	C₄₄H₅₇N₃O₁₃
Molecular Weight	859.94 g/mol
Synonyms	3-[(2-Propynyloxyimino)methyl]rifamycin SV; 3-(O-Propargyloximinomethyl)rifamycin SV; Rifamycin SV 3-(O-propargyloxime); Propargyl Oxime of Rifamycin SV; 3-Formylrifamycin SV O-(2-Propynyl)oxime; Antibiotic X 5108; (E)-3-((Prop-2-yn-1-yloxy)imino)methyl)rifamycin SV
EINECS	Contact for details

Quality Control

Our 3-[(2-Propynyl)Oxyiminomethyl]Rifamycin Sv is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC, NMR, and mass spectrometry to confirm identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure full traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Reddish-brown to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Solubility	Soluble in DMSO, methanol; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.