Description

6α-[(Hydroxyphenylacetyl)Amino]Penicillanic Acid CAS NO 4759-24-4 is a key chemical intermediate in the synthesis of semi-synthetic β-lactam antibiotics. Its primary value lies in its role as a versatile building block for creating advanced penicillin derivatives with enhanced efficacy and stability. This compound is essential for pharmaceutical manufacturers and research institutions focused on developing and producing next-generation antibacterial agents.

Application

• Pharmaceutical Intermediate: Primary use as a crucial precursor in the synthesis of semi-synthetic penicillin antibiotics, such as amoxicillin and ampicillin.
• Antibiotic Research & Development: Serves as a foundational scaffold in medicinal chemistry for designing novel β-lactam compounds with improved pharmacokinetic properties.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in controlled synthesis processes to produce high-purity antibiotic APIs under Good Manufacturing Practice (GMP) conditions.
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) of penicillin-class drugs and mechanisms of bacterial resistance.
• Process Chemistry: Utilized in scaling up and optimizing production routes for cost-effective and sustainable antibiotic manufacturing.

Basic Information

Product Name	6α-[(Hydroxyphenylacetyl)Amino]Penicillanic Acid
CAS No.	4759-24-4
Molecular Formula	C₁₆H₁₈N₂O₅S
Molecular Weight	350.39 g/mol
Synonyms	6-APA Derivative; D-(-)-α-Aminobenzylpenicillinic Acid Precursor; (2S,5R,6R)-6-[[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid; 6-[(Amino(4-hydroxyphenyl)acetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic Acid; Hydroxyphenylglycyl-6-APA; Amoxicillin Intermediate; 4-Hydroxy-α-aminobenzylpenicillinic Acid
EINECS	Contact for details

Quality Control

Our 6α-[(Hydroxyphenylacetyl)Amino]Penicillanic Acid is produced and tested to meet stringent quality standards suitable for pharmaceutical applications. We ensure high purity and batch-to-batch consistency through rigorous analytical controls, including HPLC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment. Our quality system is designed to support customer requirements for GMP and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.