Description

S(+)-Deprenyl Hydrochloride is the pharmacologically active enantiomer of the selective monoamine oxidase-B (MAO-B) inhibitor, selegiline. This high-purity chiral compound is critical for research and development in neuropharmacology, offering superior specificity compared to the racemic mixture. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and fine chemical manufacturers focused on central nervous system (CNS) therapeutics and advanced chemical synthesis.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for analytical method development, validation, and quality control testing of drug substances and products.
• Neuropharmacology Research: A key tool for studying the mechanisms of MAO-B inhibition, neuroprotection, and dopaminergic signaling in models of Parkinson's disease and cognitive disorders.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical chiral building block in the synthesis of enantiomerically pure selegiline hydrochloride and related therapeutic agents.
• Biochemical Assay Development: Employed in the development of high-throughput screening (HTS) assays and diagnostic kits targeting MAO-B enzyme activity.
• Preclinical & Clinical Studies: Utilized in formulation studies, pharmacokinetic/pharmacodynamic (PK/PD) modeling, and toxicity assessments during drug development stages.
• Asymmetric Synthesis: Acts as a valuable chiral auxiliary or precursor in sophisticated organic synthesis routes for novel chemical entities.

Basic Information

Product Name	S(+)-Deprenyl Hydrochloride
CAS No.	4528-52-3
Molecular Formula	C13H17N·HCl
Molecular Weight	223.74 g/mol
Synonyms	(R)-(-)-Deprenyl Hydrochloride; (R)-(-)-Selegiline Hydrochloride; (R)-N,α-Dimethyl-N-2-propynylphenethylamine Hydrochloride; L-Deprenyl Hydrochloride; (R)-(-)-N-Methyl-N-(1-phenyl-2-propyl)prop-2-yn-1-amine Hydrochloride; J-508; Elderpryl; E-250
EINECS	Contact for details

Quality Control

Our S(+)-Deprenyl Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤1.0%
Single Maximum Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.