Description

Teclothiazide CAS NO 4267-05-4 is a high-purity thiazide diuretic compound, serving as a critical pharmaceutical intermediate and reference standard. Its primary value lies in enabling the research, development, and quality control of antihypertensive and diuretic medications. This product is essential for pharmaceutical manufacturers, analytical laboratories, and research institutions focused on cardiovascular therapeutics and metabolic studies.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced thiazide diuretic drug substances.
• Reference Standard: Used for analytical method development, validation, and quality control (QC/QA) testing in pharmaceutical production.
• Biomedical Research: Employed in pharmacological studies to investigate diuretic mechanisms, electrolyte balance, and hypertension models.
• Impurity Profiling: Serves as a known impurity or degradation product marker in the analysis of related drug formulations.
• Chemical Synthesis: Utilized in organic synthesis for creating novel derivatives with potential therapeutic activity.

Basic Information

Product Name	Teclothiazide
CAS No.	4267-05-4
Molecular Formula	C₈H₈ClN₃O₄S₂
Molecular Weight	317.76 g/mol
Synonyms	6-Chloro-3,4-dihydro-3-(2,2,2-trifluoroethylthio)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide; 6-Chloro-3-(2,2,2-trifluoroethylthio)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide; Teclothiazide; Ticrynafen; ANP 3624; Diflurex; Selacryn
EINECS	224-247-5

Quality Control

Our Teclothiazide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC and other pharmacopeial methods, to ensure it meets stringent specifications for pharmaceutical use. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.