Description

Canrenoic Acid CAS NO 4138-96-9 is a steroidal compound primarily known as the active metabolite of the potassium-sparing diuretic spironolactone. This high-purity pharmaceutical intermediate is critical for research and development in cardiovascular and renal pharmacology. It is essential for manufacturers and research institutions focused on developing and producing novel diuretic agents, studying mineralocorticoid receptor antagonists, and creating analytical reference standards.

Application

• Pharmaceutical Intermediate: Key starting material or precursor in the synthesis of spironolactone and related diuretic drugs.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the production of finished dosage forms for treating hypertension, heart failure, and edema.
• Biochemical Research: Vital tool for studying the mechanism of action of aldosterone antagonists at the mineralocorticoid receptor.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical labs.
• Metabolite Studies: Used in pharmacokinetic and metabolic pathway research to understand drug behavior in biological systems.
• Formulation Development: Employed in pre-formulation studies for developing stable and effective drug products.

Basic Information

Product Name	Canrenoic Acid
CAS No.	4138-96-9
Molecular Formula	C22H28O4
Molecular Weight	356.46 g/mol
Synonyms	Canrenoate; 6β,7β;15β,16β-Dimethylen-3-oxo-17α-pregn-4-ene-21,17-carbolactone; 17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid γ-lactone; SC-14266; Aldactone metabolite; Potassium canrenoate (salt form); Spironolactone metabolite
EINECS	223-943-8

Quality Control

Our Canrenoic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets stringent specifications for pharmaceutical use. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing compliance with relevant standards. Our quality commitment supports applications requiring GMP-grade materials and research standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.