Description

Polymyxin B(1) is a potent polypeptide antibiotic belonging to the polymyxin class, specifically isolated from the bacterium *Bacillus polymyxa*. This compound is critically important for its bactericidal activity against a wide range of Gram-negative pathogens, including multi-drug resistant strains. It is an essential raw material for the pharmaceutical industry, primarily used in the formulation of topical and injectable medications, as well as in advanced research applications. Our supply of Polymyxin B(1) CAS NO 4135-11-9 is characterized by high purity and stringent quality control to meet the demanding needs of global pharmaceutical manufacturing and life science research.

Application

• Pharmaceutical Active Ingredient (API): Core component in the manufacture of injectable and topical antibiotic formulations for treating serious systemic and localized Gram-negative infections.
• Ophthalmic Preparations: Used in eye drops and ointments to combat bacterial conjunctivitis and corneal ulcers.
• Veterinary Medicine: Incorporated into treatments for bacterial infections in livestock and companion animals.
• Research & Development: Serves as a critical reference standard and tool compound in microbiological studies, antibiotic resistance research, and novel drug discovery programs.
• Cell Culture & Microbiology: Used in selective media to prevent bacterial contamination in cell culture laboratories.
• Combination Therapies: Formulated with other antibiotics to create synergistic effects and broaden the spectrum of antimicrobial activity.

Basic Information

Item	Detail
Product Name	Polymyxin B(1)
CAS No.	4135-11-9
Molecular Formula	C56H98N16O13
Molecular Weight	1203.5 g/mol
Synonyms	Polymyxin B1; Polymyxin B Sulfate (component); Aerosporin; Polyfax; Polymyxin B Nonapeptide (related derivative); Polymyxin E1 (Colistin A, related compound); [L-Dab]1 Polymyxin B1; Antibiotic 414; Polymyxin B Component 1
EINECS	223-953-6

Quality Control

Our Polymyxin B(1) is manufactured and tested under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and potency, identification by spectroscopic methods, and stringent tests for related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with relevant pharmacopeial standards (e.g., USP, EP) for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Polymyxin B2 Content	≤ 5.0%
Water Content (KF)	≤ 10.0%
pH (1% solution)	5.0 - 7.5
Residue on Ignition	≤ 1.0%
Bacterial Endotoxins	< 2.0 EU/mg (for injectable grade)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.