Description

R(-)-Norapomorphine HBr is a high-purity, enantiomerically pure derivative of the aporphine class of alkaloids, serving as a critical chiral building block and reference standard. This compound is valued for its potent and selective dopaminergic activity, making it an essential tool in advanced pharmacological research and development. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on neuroscience, neuropharmacology, and the synthesis of novel therapeutic agents.

Application

• Pharmacological Research: Acts as a key reference standard and active compound in studies targeting dopamine D1 and D2 receptors for neurological disorders.
• Neuroscience Studies: Used in vitro and in vivo to investigate dopaminergic pathways, receptor binding affinity, and signal transduction mechanisms.
• Drug Discovery & Development: Serves as a chiral intermediate or lead compound in the synthesis of potential therapeutics for Parkinson's disease, schizophrenia, and addiction.
• Analytical Standard: Employed as a high-purity calibrant in HPLC, LC-MS, and other chromatographic methods for quality control and method validation.
• Biochemical Assays: Utilized in enzyme inhibition studies and functional cellular assays to elucidate specific biological activities.

Basic Information

Product Name	R(-)-Norapomorphine HBr
CAS No.	478-76-2
Molecular Formula	C₁₆H₁₇NO₂ • HBr
Molecular Weight	344.22 g/mol
Synonyms	R-(-)-Norapomorphine hydrobromide; (-)-Norapomorphine HBr; (R)-Norapomorphine HBr; 6aβ-Aporphine-10,11-diol hydrobromide; (R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol hydrobromide; R(-)-N-norapomorphine hydrobromide; Norapomorphine HBr
EINECS	Contact for details

Quality Control

Every batch of R(-)-Norapomorphine HBr is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and compliance documentation. A detailed Certificate of Analysis (COA) specifying results for assay, chiral purity, related substances, and residual solvents is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R-isomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.