Description

Naloxone CAS NO 465-65-6 is a potent opioid antagonist, chemically known as 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride. It is a critical pharmaceutical active ingredient used to rapidly reverse the life-threatening effects of opioid overdose. This compound is essential for manufacturers in the pharmaceutical industry producing emergency treatment kits, injectable solutions, and nasal sprays. Its high purity and reliable efficacy are paramount for ensuring patient safety in clinical and community settings.

Application

• Pharmaceutical Formulations: Primary active ingredient in emergency opioid overdose reversal medications (e.g., injectables, auto-injectors, nasal sprays).
• Hospital & Emergency Medicine: Used in hospital settings for the management of postoperative opioid depression and overdose in critical care.
• Community Harm Reduction: Key component in take-home naloxone kits distributed to first responders, community organizations, and at-risk individuals.
• Veterinary Medicine: Employed to reverse opioid-induced respiratory depression in animals during surgical procedures.
• Analytical Reference Standard: Serves as a high-purity standard in pharmaceutical research, quality control laboratories, and forensic analysis.
• Clinical Research: Used in studies investigating opioid receptor mechanisms, addiction treatment protocols, and new drug delivery systems.

Basic Information

Product Name	Naloxone
CAS No.	465-65-6
Molecular Formula	C19H21NO4 (Free base)
Molecular Weight	327.37 g/mol (Free base)
Synonyms	Naloxone Hydrochloride; 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one; EN-1530; N-allylnoroxymorphone; Narcan® (brand name); Nalone; Narcanti; (-)-Naloxone
EINECS	207-366-9

Quality Control

Our Naloxone is manufactured under strict quality management systems to meet the exacting standards of the global pharmaceutical industry. Each batch is subjected to comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis, to ensure compliance with major pharmacopoeial standards such as USP and EP. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and product integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.