Description

3-Fluorocinnamic acid (CAS NO 458-46-8) is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. Its core value lies in the strategic introduction of a fluorine atom onto the cinnamic acid scaffold, enabling precise modulation of electronic properties, lipophilicity, and metabolic stability in target molecules. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel fluorinated drug candidates, including kinase inhibitors and anti-inflammatory agents.
• Agrochemical Synthesis: Used in creating advanced fluorinated pesticides and herbicides, where the fluorine atom enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated mesogens and electron-transport materials, improving device performance and stability.
• Peptide Mimetics & Bio-conjugation: The carboxylic acid group allows for coupling to peptides or biomolecules, creating fluorinated probes and conjugates for biochemical studies.
• Polymer Modification: Incorporated into polymer backbones to alter physical properties such as thermal stability, solubility, and refractive index.
• Chemical Research & Development: A versatile starting material for Suzuki-Miyaura coupling, Heck reactions, and other cross-coupling methodologies to construct complex fluorinated architectures.

Basic Information

Product Name	3-Fluorocinnamic acid
CAS No.	458-46-8
Molecular Formula	C9H7FO2
Molecular Weight	166.15 g/mol
Synonyms	(E)-3-(3-Fluorophenyl)acrylic acid; 3-Fluorocinnamic Acid; trans-3-Fluorocinnamic Acid; 3-Fluorobenzeneacrylic Acid; (3-Fluorophenyl)acrylic Acid; m-Fluorocinnamic Acid; 3-Fluorocinnameic Acid; 458-46-8
EINECS	Contact for details

Quality Control

Our 3-Fluorocinnamic acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure compliance with exacting R&D and production standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Approx. 142-146 °C
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.