Description

Benzoyl Fluoride, 4-Chloro- CAS NO 456-21-3 is a specialized organofluorine compound featuring a benzoyl group substituted with both fluorine and chlorine atoms. This unique structure makes it a valuable high-purity building block in advanced chemical synthesis, particularly for introducing fluorinated aromatic moieties. It is primarily utilized by pharmaceutical R&D teams and agrochemical manufacturers seeking to develop novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially those requiring fluorinated aromatic structures for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the introduction of fluorine can enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorine-containing functional groups into polymer chains, altering surface properties, chemical resistance, and thermal stability.
• Organic Synthesis Reagent: Acts as a versatile reagent in Friedel-Crafts acylation and other reactions to synthesize complex, fluorinated organic molecules for research and specialty chemicals.

Basic Information

Product Name	Benzoyl Fluoride, 4-Chloro-
CAS No.	456-21-3
Molecular Formula	C7H4ClFO
Molecular Weight	158.56 g/mol
Synonyms	4-Chlorobenzoyl Fluoride; p-Chlorobenzoyl Fluoride; 4-Chlorobenzoic Acid Fluoride; 1-(Chloro-4-phenyl)-1-fluoromethanone; Benzoyl fluoride, 4-chloro-; p-Chlorobenzoyl fluoride; 4-Chloro-1-fluorobenzene-1-carbaldehyde (incorrect but common misnomer)
EINECS	Contact for details

Quality Control

Our production of Benzoyl Fluoride, 4-Chloro- adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your synthetic processes. Each lot undergoes comprehensive analytical testing, including chromatographic purity assays and identity confirmation. A Certificate of Analysis (COA) detailing specific results is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain purity. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.