Description

1,3-Benzenedicarboxylic Acid, 4-Fluoro-, 1-Methyl Ester is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty polymers, where the introduction of fluorine atoms is critical for modulating biological activity and material properties. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries seeking to incorporate a fluorinated isophthalate moiety into their target molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, anti-cancer agents, and CNS-active compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atom enhances lipophilicity and metabolic stability.
• Polymer & Material Science: Serves as a monomer or co-monomer for creating high-performance polymers, such as polyesters and polyamides, with improved thermal stability and chemical resistance.
• Liquid Crystal & OLED Materials: Acts as a precursor for fluorinated aromatic cores used in electronic display materials and organic light-emitting diodes (OLEDs).
• Organic Synthesis Reagent: Employed in cross-coupling reactions, esterifications, and other transformations to introduce functionalized aromatic systems.
• Chemical Research & Development: A valuable reference standard and starting material for academic and industrial research exploring new fluorinated compounds.

Basic Information

Product Name	1,3-Benzenedicarboxylic Acid, 4-Fluoro-, 1-Methyl Ester
CAS No.	387882-89-5
Molecular Formula	C10H7FO4
Molecular Weight	210.16 g/mol
Synonyms	4-Fluoroisophthalic Acid 1-Methyl Ester; Methyl 4-Fluoroisophthalate; 1-Methyl 4-Fluoroisophthalate; 4-Fluoro-1,3-benzenedicarboxylic Acid 1-Methyl Ester; 4-Fluorobenzene-1,3-dicarboxylic Acid Monomethyl Ester; 4-Fluoroisophthalic Acid Monomethyl Ester; 1-Carbomethoxy-3-carboxy-4-fluorobenzene
EINECS	Contact for details

Quality Control

Our 1,3-Benzenedicarboxylic Acid, 4-Fluoro-, 1-Methyl Ester is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay and impurity profiles. For customers with specific regulatory needs, we can support documentation for cGMP and ISO standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The product may be moisture-sensitive; ensure containers are sealed tightly after use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.