Description

2,4,5-Trifluoromandelic Acid is a high-value fluorinated aromatic building block essential for advanced organic synthesis. This compound is critical for introducing the trifluoromethyl-hydroxy-acetic acid pharmacophore, which can significantly alter the physicochemical and biological properties of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and sophisticated intermediates.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in protease inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine atoms enhance bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty monomers and polymers with tailored properties for high-performance materials.
• Chemical Biology Probes: Useful for creating fluorinated analogs of natural products and biochemical probes for mechanism-of-action studies.

Basic Information

Product Name	2,4,5-Trifluoromandelic Acid
CAS No.	375369-29-2
Molecular Formula	C8H5F3O3
Molecular Weight	206.12 g/mol
Synonyms	2,4,5-Trifluoro-α-hydroxybenzeneacetic Acid; (2,4,5-Trifluorophenyl)(hydroxy)acetic Acid; α-Hydroxy-2,4,5-trifluorophenylacetic Acid; DL-2,4,5-Trifluoromandelic Acid; (±)-2,4,5-Trifluoromandelic Acid; 2,4,5-Trifluorophenylglycolic Acid; 375369-29-2; Mandelic acid, 2,4,5-trifluoro-
EINECS	Contact for details

Quality Control

Our 2,4,5-Trifluoromandelic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for research and production use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.