Description

Dna, D(p-Thio) (C-T-A-G-A-T-T-T-C-C-C-G-C-G), Tridecasodium Salt is a chemically modified oligonucleotide sequence where specific phosphate groups are replaced with phosphorothioate (p-Thio) linkages, conferring enhanced nuclease resistance and stability. This modification is critical for applications requiring prolonged biological activity and robust performance in complex environments. It is an essential research and diagnostic reagent for molecular biology laboratories, pharmaceutical R&D, and biotechnology companies focused on antisense technology, gene silencing studies, and advanced nucleic acid-based assay development.

Application

• Antisense Oligonucleotide (ASO) Research: Serves as a stable, nuclease-resistant probe for studying gene function and regulation.
• Diagnostic Probe Development: Used in the design of sensitive and specific hybridization probes for pathogen detection and genetic testing.
• Therapeutic Nucleic Acid Precursor: A key intermediate in the development of phosphorothioate-backbone therapeutic oligonucleotides.
• Biophysical Studies: Employed in structural analysis and binding affinity studies due to its modified backbone properties.
• PCR and Amplification Controls: Acts as a stable internal control or template in nucleic acid amplification techniques.
• Surface Immobilization: The thio-modification facilitates conjugation to gold surfaces or maleimide-activated supports for biosensor and microarray applications.

Basic Information

Product Name	Dna, D(p-Thio) (C-T-A-G-A-T-T-T-C-C-C-G-C-G), Tridecasodium Salt
CAS No.	362543-73-5
Molecular Formula	C130H147N52Na13O78P13S13
Molecular Weight	Contact for details
Synonyms	Phosphorothioate Oligodeoxyribonucleotide (Sequence: 5'-CTA GAT TTC CCG CG-3'); PS-ODN; Thioated DNA Oligomer; Antisense Oligonucleotide Sequence; d(pS) (C-T-A-G-A-T-T-T-C-C-C-G-C-G), Tridecasodium Salt; 5'-Cps Tps Aps Gps Aps Tps Tps Tps Cps Cps Cps Gps Cps G-3' Tridecasodium Salt; DNA Oligonucleotide with Phosphorothioate Backbone
EINECS	Contact for details

Quality Control

Every batch of our oligonucleotides is synthesized under GMP-like conditions and undergoes a comprehensive suite of analytical tests to ensure identity, purity, and consistency. Standard quality control includes HPLC for purity analysis, Mass Spectrometry (MS) for sequence confirmation, and endotoxin testing where applicable. A detailed Certificate of Analysis (COA) providing full specification results is supplied with each shipment, ensuring compliance with rigorous research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference
Purity (Analytical HPLC)	≥ 95%
Oligonucleotide Content (UV)	≥ 80%
Endotoxin	< 10 EU/mg
Solubility	Soluble in water, TE buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.