Description

1-(4-Fluorobenzoyl)Piperidine-2-Carboxylic Acid is a high-purity fluorinated piperidine derivative, serving as a critical advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its value lies in enabling the development of novel bioactive molecules, particularly for central nervous system (CNS) and metabolic disorder research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate a fluorinated benzoyl-piperidine scaffold into their target compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, especially in neurological and psychiatric therapeutic areas.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to explore new pharmacophores.
• Agrochemical Synthesis: Intermediate in the development of novel pesticides and herbicides leveraging the fluorinated aromatic moiety.
• Fine Chemical Production: Serves as a precursor for specialty chemicals, ligands, and catalysts used in asymmetric synthesis.
• Academic & Institutional R&D: Utilized in universities and research institutes for methodological development and novel compound library generation.
• Contract Manufacturing (CMO/CDMO): Supplied to outsourcing partners for scale-up and custom synthesis projects under cGMP guidelines.

Basic Information

Product Name	1-(4-Fluorobenzoyl)Piperidine-2-Carboxylic Acid
CAS No.	351902-40-4
Molecular Formula	C13H14FNO3
Molecular Weight	251.26 g/mol
Synonyms	2-Piperidinecarboxylic acid, 1-(4-fluorobenzoyl)-; 1-(4-Fluorobenzoyl)pipecolic acid; (4-Fluorobenzoyl)pipecolic acid; 4-Fluoro-α-oxo-benzenepropanoic acid 1-piperidinecarboxylic acid cyclic amide; 1-(4-Fluorobenzoyl)-2-piperidinecarboxylic acid; 1-(4-Fluorobenzoyl)piperidine-2-carboxylic acid; 351902-40-4; 1-(4-Fluorobenzoyl)pipecolate
EINECS	Contact for details

Quality Control

Our 1-(4-Fluorobenzoyl)Piperidine-2-Carboxylic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support audits and regulatory documentation for cGMP compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.