Description

5-Bromo-2-Chloro-4-Fluoro-Benzoic Acid Ethyl Ester is a high-purity, multi-halogenated benzoic acid derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile, functionalized aromatic core for constructing complex molecules, particularly in pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists working on new active ingredients, where its specific halogen pattern enables precise structural modifications.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitor and anti-cancer drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the halogenated aromatic system contributes to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, liquid crystals, and advanced polymers requiring halogenated aromatic monomers.
• Custom Synthesis and Contract Manufacturing: A starting material for custom chemical synthesis services catering to the fine chemical and life science industries.

Basic Information

Product Name	5-Bromo-2-Chloro-4-Fluoro-Benzoic Acid Ethyl Ester
CAS No.	351325-30-9
Molecular Formula	C9H7BrClFO2
Molecular Weight	281.51 g/mol
Synonyms	Ethyl 5-Bromo-2-Chloro-4-Fluorobenzoate; Benzoic acid, 5-bromo-2-chloro-4-fluoro-, ethyl ester; 2-Chloro-5-bromo-4-fluorobenzoic acid ethyl ester; 4-Fluoro-5-bromo-2-chlorobenzoic acid ethyl ester; 351325-30-9; 5-Br-2-Cl-4-F-Bz-OEt
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-2-Chloro-4-Fluoro-Benzoic Acid Ethyl Ester adheres to stringent quality management protocols. Every batch is analyzed using advanced techniques including HPLC, GC, and NMR to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality system is designed to support cGMP and ISO standards for reliable supply to regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Meets ICH guidelines
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.