Description

4-(Boc-Amino)Methyl-2-Fluoro-Benzoic Acid is a high-purity, protected amino acid derivative that serves as a critical building block in advanced organic synthesis. This compound is essential for the controlled introduction of a fluorinated benzoic acid moiety with a protected amine functional group, enabling complex molecular construction. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of complex drug candidates, particularly for oncology and CNS-targeted therapies.
• Peptide Mimetics & PROTACs: Used to incorporate fluorinated aromatic structures into peptide backbones and proteolysis-targeting chimeras (PROTACs).
• Agrochemical Research: Serves as a precursor in developing novel herbicides and pesticides with enhanced stability and bioavailability.
• Fluorine Chemistry: A valuable substrate for studying structure-activity relationships (SAR) due to the presence of the fluorine atom.
• Linker Chemistry: Employed in the construction of chemical linkers for bioconjugation and antibody-drug conjugates (ADCs).
• Material Science: Used in the research and development of specialty polymers and advanced organic frameworks.

Basic Information

Product Name	4-(Boc-Amino)Methyl-2-Fluoro-Benzoic Acid
CAS No.	335155-19-6
Molecular Formula	C₁₄H₁₈FNO₄
Molecular Weight	283.30 g/mol
Synonyms	2-Fluoro-4-[(tert-butoxycarbonylamino)methyl]benzoic acid; 4-[(Boc-amino)methyl]-2-fluorobenzoic acid; 4-(N-Boc-aminomethyl)-2-fluorobenzoic acid; tert-Butyl N-[(4-carboxy-3-fluorophenyl)methyl]carbamate; Benzoic acid, 2-fluoro-4-[[[(1,1-dimethylethoxy)carbonyl]amino]methyl]-; Boc-4-Aminomethyl-2-fluorobenzoic Acid
EINECS	Contact for details

Quality Control

Our 4-(Boc-Amino)Methyl-2-Fluoro-Benzoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect product stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.