Description

(R)-(+)-Tolvaptan CAS NO 331947-66-1 is the pharmacologically active enantiomer of the selective, non-peptide vasopressin V2 receptor antagonist. This high-purity chiral intermediate is critical for the synthesis of advanced pharmaceutical compounds where stereochemical integrity directly impacts therapeutic efficacy and safety. It is primarily required by pharmaceutical R&D laboratories and manufacturers engaged in the development and production of novel cardiovascular and renal therapies.

Application

• Key chiral building block for the synthesis of Tolvaptan API (Active Pharmaceutical Ingredient).
• Critical intermediate in pharmaceutical research for developing vasopressin receptor antagonists.
• Used in preclinical and clinical studies for conditions like hyponatremia and autosomal dominant polycystic kidney disease (ADPKD).
• Reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• Starting material for the preparation of deuterated or other isotopically labeled analogs for metabolic studies.
• Intermediate in the synthesis of novel chemical entities targeting G-protein-coupled receptors (GPCRs).

Basic Information

Product Name	(R)-(+)-Tolvaptan
CAS No.	331947-66-1
Molecular Formula	C₂₆H₂₅ClN₂O₃
Molecular Weight	448.94 g/mol
Synonyms	(+)-Tolvaptan; (R)-Tolvaptan; Tolvaptan Impurity R; (R)-5-Demethyltolvaptan; 7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylaminobenzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepine; OPC-41061 (R-enantiomer); SR-121463 (R-enantiomer); (3R)-7-Chloro-3,4-dihydro-5-hydroxy-3-[4-(2-methyl-2-benzoylamino)benzoyl]-2H-1-benzazepine-1-acetic acid
EINECS	Contact for details

Quality Control

Our (R)-(+)-Tolvaptan is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including chiral purity assay, identification, and impurity profiling to ensure it meets stringent specifications for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific client or regulatory requirements (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (R-enantiomer)
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.