Description

(S)-(-)-Tolvaptan is the single enantiomer form of the selective, competitive vasopressin V2-receptor antagonist. This high-purity chiral intermediate is critical for the synthesis of advanced pharmaceutical active ingredients. It is primarily utilized by research institutions and pharmaceutical manufacturers developing novel therapeutics for conditions like hyponatremia and polycystic kidney disease. Consistent quality and reliable supply are paramount for ensuring the integrity of downstream drug development and production processes.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of Tolvaptan API and its analogs.
• Drug Discovery & Development: Used in preclinical and clinical research to study vasopressin receptor antagonism.
• Reference Standard: Serves as a high-purity standard for analytical method development and quality control in API manufacturing.
• Asymmetric Synthesis: Employed in research exploring novel synthetic pathways for complex chiral molecules.
• Metabolite Studies: Utilized in the preparation and identification of drug metabolites for pharmacokinetic research.

Basic Information

Product Name	(S)-(-)-Tolvaptan
CAS No.	331947-44-5
Molecular Formula	C26H25ClN2O3
Molecular Weight	448.94 g/mol
Synonyms	(2R,4S)-5-(5'-Chloro-2'-oxobenzimidazol-1'-yl)-2-methyl-4-o-tolylpiperidine-1-carboxamide; (S)-Tolvaptan; UNII-21G72T1950; Tolvaptan Impurity; (S)-(-)-5-Chloro-1-[1-(4-hydroxybenzoyl)-2,3-dihydro-2-methyl-1H-indol-5-yl]sulfonyl-3-phenyl-2-propyl-1H-indole; OPC-41061 (enantiomer)
EINECS	Contact for details

Quality Control

Our (S)-(-)-Tolvaptan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D use. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.