Description

2,3,4-Trifluorocinnamic Acid is a high-value fluorinated aromatic building block characterized by its cinnamic acid backbone with a specific trifluoro substitution pattern. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceuticals and agrochemicals, where the fluorine atoms enhance metabolic stability, bioavailability, and binding affinity. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and CNS-targeting drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the fluorine atoms contribute to efficacy and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated organic semiconductors and liquid crystal compounds used in display technologies.
• Peptide Mimetics & Bio-conjugation: The carboxylic acid group allows for coupling reactions to create fluorinated peptide analogs or for labeling biomolecules.
• Polymer Modification: Incorporated as a monomer or modifier to impart unique solubility and stability properties to specialty polymers.
• Chemical Research & Development: A versatile reagent for exploring new fluorination chemistry and structure-activity relationships (SAR) in medicinal chemistry programs.

Basic Information

Product Name	2,3,4-Trifluorocinnamic Acid
CAS No.	331776-45-5
Molecular Formula	C9H5F3O2
Molecular Weight	202.13 g/mol
Synonyms	(2E)-3-(2,3,4-Trifluorophenyl)prop-2-enoic acid; 2,3,4-Trifluorocinnamic acid; trans-2,3,4-Trifluorocinnamic Acid; (E)-3-(2,3,4-Trifluorophenyl)acrylic acid; β-(2,3,4-Trifluorophenyl)acrylic acid; 2,3,4-Trifluoro-trans-cinnamic acid; 331776-45-5; 2,3,4-Trifluorocinammic Acid
EINECS	Contact for details

Quality Control

Our 2,3,4-Trifluorocinnamic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.