Description

Edifoligide is a synthetic oligonucleotide-based compound with significant research and therapeutic potential. This molecule is primarily valued for its role as an E2F decoy, a mechanism that allows it to modulate specific cellular pathways involved in proliferation. It is a critical material for researchers and developers in the pharmaceutical and biotechnology sectors. Key applications include its investigation in the prevention of vascular graft failure and other conditions related to abnormal cell growth.

Application

• Pharmaceutical Research & Development: As a key investigational agent for studying cell cycle regulation and gene expression.
• Vascular Biology Studies: Primary research into the prevention of neointimal hyperplasia, a common cause of graft failure after vascular surgery.
• Preclinical Development: Serves as an active pharmaceutical ingredient (API) in formulation studies for potential therapeutic applications.
• Biochemical Research: Used as a tool compound to inhibit E2F transcription factor activity in various in vitro and in vivo models.
• Academic Research: Fundamental studies in oncology, cardiology, and molecular biology to understand pathways controlling cell proliferation.

Basic Information

Product Name	Edifoligide
CAS No.	328538-04-1
Molecular Formula	C204H247N78O115P19S19
Molecular Weight	6331.0 g/mol (approx.)
Synonyms	E2F Decoy; CGT-003; Edifoligide sodium; ODN E2F; E2F Transcription Factor Decoy; Oligonucleotide E2F Decoy; 5'-d(CCT TTT CGC GCC)-3' (Phosphorothioate); GTI-2040 (related sequence); Gene therapy inhibitor for E2F.
EINECS	Contact for details

Quality Control

Our Edifoligide is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing including HPLC for purity and assay, mass spectrometry for identity confirmation, and tests for residual solvents and endotoxins. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade and cGMP standards where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate and keep under inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (UV)	90.0% - 110.0% of stated amount
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg
Sterility (for sterile grade)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.