Description

Dmtr-Fna-C(Bz)Phosphoramidite CAS NO 326802-62-4 is a specialized phosphoramidite monomer, a critical building block in the automated solid-phase synthesis of oligonucleotides. This compound is engineered for high coupling efficiency and purity, which are essential for producing reliable and consistent nucleic acid sequences. It is primarily required by manufacturers and research institutions in the fields of therapeutic oligonucleotide development, diagnostic probe synthesis, and academic research.

Application

• Oligonucleotide Synthesis: As a key monomer for the solid-phase synthesis of DNA and RNA strands, particularly for introducing modified bases.
• Therapeutic Development: Production of antisense oligonucleotides (ASOs), siRNA, and aptamers for pharmaceutical applications.
• Diagnostic Probes: Manufacture of labeled probes for genetic testing, fluorescence in situ hybridization (FISH), and microarray technologies.
• Research Reagents: Used in academic and industrial R&D for studying gene function, regulation, and for PCR primer synthesis.
• Next-Generation Sequencing (NGS): Synthesis of custom primers and adapters used in library preparation for genomic sequencing.
• CRISPR/Cas9 Systems: Synthesis of guide RNAs (gRNAs) and other nucleic acid components for gene editing workflows.

Basic Information

Product Name	Dmtr-Fna-C(Bz)Phosphoramidite
CAS No.	326802-62-4
Molecular Formula	C41H42N3O8P
Molecular Weight	735.76 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluoro-N4-benzoyl-2'-arabino-cytidine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 5'-O-DMT-2'-F-N4-Bz-2'-ara-C Phosphoramidite; 2'-Fluoro-2'-arabino-cytidine Phosphoramidite (N4-Bz, 5'-DMT); 2'-F-ara-C Phosphoramidite; DMT-2'F-ara-C(Bz)-CE Phosphoramidite; 2'-Deoxy-2'-fluoro-arabinocytidine phosphoramidite derivative
EINECS	Contact for details

Quality Control

Every batch of Dmtr-Fna-C(Bz)Phosphoramidite is manufactured and tested under strict quality management systems. Our products undergo rigorous quality testing to ensure compliance with industry standards for oligonucleotide synthesis. Certificates of Analysis (COA) detailing purity, identity, and moisture content are available upon request. We support compliance with GMP and ISO 9001 guidelines for critical raw materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (argon or nitrogen) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Moisture (Karl Fischer)	≤ 0.5%
Solubility	Clear, colorless solution in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.