Description

3-(4-Difluoromethoxy-3-Methoxy-Phenyl)-Acrylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its distinct aromatic and acrylic acid functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting specific receptor pathways. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new therapeutic agents and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially for central nervous system (CNS) and anti-inflammatory drugs.
• Agrochemical Research: Serves as a precursor in the development of new-generation herbicides and fungicides with specific mode-of-action profiles.
• Organic Synthesis: Used in research laboratories for constructing complex organic molecules via reactions like Heck coupling or Michael additions, leveraging its acrylic acid moiety.
• Material Science: Investigated as a monomer or cross-linking agent for creating specialized polymers with unique optical or electronic properties.
• Bioconjugation: The carboxylic acid group enables its use as a linker molecule for attaching fluorophores or other probes in diagnostic assay development.

Basic Information

Item	Details
Product Name	3-(4-Difluoromethoxy-3-Methoxy-Phenyl)-Acrylic Acid
CAS No.	324579-78-4
Molecular Formula	C11H10F2O4
Molecular Weight	244.19 g/mol
Synonyms	3-(4-(Difluoromethoxy)-3-methoxyphenyl)acrylic acid; (E)-3-(4-(Difluoromethoxy)-3-methoxyphenyl)acrylic acid; 3-(4-Difluoromethoxy-3-methoxy-phenyl)-2-propenoic acid; 4-Difluoromethoxy-3-methoxycinnamic acid; DFMOPA; 324579-78-4; Acrylic acid, 3-[4-(difluoromethoxy)-3-methoxyphenyl]-
EINECS	Contact for details

Quality Control

Every batch of 3-(4-Difluoromethoxy-3-Methoxy-Phenyl)-Acrylic Acid is manufactured and tested under a strict quality management system. We ensure compliance with ICH Q7 guidelines for pharmaceutical intermediates. Our comprehensive analytical suite includes HPLC, GC, NMR, and MS to verify identity, purity, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support customer audits and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.