Description

6-Fluoro-4H-1,3-Benzodioxine-8-Carboxylic Acid is a high-value fluorinated heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the fluorine atom and benzodioxine scaffold impart desirable biological activity and metabolic stability. It is primarily needed by research and development chemists, process development teams, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used to construct novel herbicides and fungicides, leveraging the fluorine atom to enhance bioavailability and environmental persistence.
• Material Science Research: Serves as a monomer or functionalizing agent for creating specialty polymers with unique optical or electronic properties.
• Ligand and Catalyst Development: The carboxylic acid functionality allows for derivatization into complex chelating ligands for catalytic systems.
• Chemical Biology Probes: Employed in the design of fluorinated molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects.

Basic Information

Product Name	6-Fluoro-4H-1,3-Benzodioxine-8-Carboxylic Acid
CAS No.	321309-28-8
Molecular Formula	C9H5FO4
Molecular Weight	196.13 g/mol
Synonyms	6-Fluoro-1,3-benzodioxine-8-carboxylic acid; 6-Fluoro-4H-benzo[1,3]dioxine-8-carboxylic acid; 8-Carboxy-6-fluoro-4H-1,3-benzodioxine; 6-Fluoro-8-carboxy-4H-1,3-benzodioxine; 321309-28-8; 6-Fluoro-4H-1,3-benzodioxin-8-carboxylic acid
EINECS	Contact for details

Quality Control

Our 6-Fluoro-4H-1,3-Benzodioxine-8-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly closed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.