Description

2-Acetyl-3,6-Difluorobenzoic Acid is a high-purity fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where the difluoroacetylbenzoic acid moiety can impart desirable biological activity and metabolic stability. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate this specific fluorinated scaffold into novel molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting enzymes and receptors.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where fluorine atoms enhance efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced polymers and organic electronic materials that require fluorinated aromatic components.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.
• Academic and R&D Laboratories: Used in fundamental research exploring new organic reactions and the properties of fluorinated compounds.

Basic Information

Item	Details
Product Name	2-Acetyl-3,6-Difluorobenzoic Acid
CAS No.	319457-34-6
Molecular Formula	C9H6F2O3
Molecular Weight	200.14 g/mol
Synonyms	3,6-Difluoro-2-acetylbenzoic Acid; 2-Acetyl-3,6-difluorobenzoic Acid; Benzoic acid, 2-acetyl-3,6-difluoro-; 319457-34-6; 3,6-Difluoro-α-oxo-o-toluic Acid; 2-Acetyl-3,6-difluorobenzoic acid (CAS 319457-34-6); α-Oxo-3,6-difluoro-o-toluic Acid
EINECS	Contact for details

Quality Control

Every batch of 2-Acetyl-3,6-Difluorobenzoic Acid is produced and tested under a strict quality management system. We ensure high purity and consistency through advanced analytical techniques including HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.