Description

3-(Chloro-Difluoro-Methoxy)-Benzoyl Fluoride is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular scaffold, which incorporates both a reactive benzoyl fluoride group and a chloro-difluoromethoxy moiety, enabling precise structural modifications. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in areas requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides where the difluoromethoxy group can impart specific biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a critical intermediate in the production of fluorinated aromatic compounds for electronic display and lighting applications.
• Advanced Polymer Modification: Employed to introduce fluorinated side chains into polymers, altering their surface properties, chemical resistance, and thermal stability.
• Cross-Coupling Reactions: The benzoyl fluoride group can act as an electrophile in palladium-catalyzed cross-coupling reactions for carbon-carbon bond formation.
• Fluorination Reagent Research: Investigated as a potential reagent or precursor for novel fluorination methodologies in organic chemistry.

Basic Information

Product Name	3-(Chloro-Difluoro-Methoxy)-Benzoyl Fluoride
CAS No.	39161-74-5
Molecular Formula	C8H4ClF3O2
Molecular Weight	224.56 g/mol
Synonyms	3-(Chlorodifluoromethoxy)benzoyl Fluoride; m-(Chlorodifluoromethoxy)benzoyl Fluoride; Benzoyl fluoride, 3-(chlorodifluoromethoxy)-; 3-(Chlorodifluoromethoxy)benzoic acid fluoride; 1-[3-(Chlorodifluoromethoxy)phenyl]-1-fluoromethanone
EINECS	Contact for details

Quality Control

Every batch of 3-(Chloro-Difluoro-Methoxy)-Benzoyl Fluoride is produced and analyzed under strict quality management protocols. Our products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation, to ensure consistency and compliance with customer specifications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.