Description

Carbidopa Monohydrate is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) primarily used in combination therapies for Parkinson's disease. Its value lies in its ability to inhibit peripheral decarboxylation of levodopa, thereby increasing the amount of levodopa available to cross the blood-brain barrier and enhancing therapeutic efficacy. This compound is essential for manufacturers in the global pharmaceutical industry, particularly those producing anti-Parkinsonian medications, advanced drug formulations, and clinical research materials.

Application

• Pharmaceutical API: Core component in combination tablets with levodopa for the treatment of Parkinson's disease and parkinsonism.
• Drug Formulation: Used in the development and production of extended-release, controlled-release, and other advanced oral dosage forms.
• Clinical Research: Serves as a critical reference standard and raw material in pharmacokinetic and pharmacodynamic studies.
• Generic Drug Manufacturing: A key ingredient for producers of generic versions of branded anti-Parkinsonian medications.
• Biochemical Research: Employed in laboratory studies investigating catecholamine metabolism and enzyme (aromatic L-amino acid decarboxylase) inhibition.
• Veterinary Medicine: Potential application in veterinary neurology for similar therapeutic mechanisms in animals.

Basic Information

Product Name	Carbidopa Monohydrate
CAS No.	38821-49-7
Molecular Formula	C10H14N2O4 • H2O
Molecular Weight	244.24 g/mol
Synonyms	L-α-Hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic Acid Monohydrate; (S)-3-(3,4-Dihydroxybenzyl)-2-hydrazino-2-methylpropionic Acid Monohydrate; MK-486 Monohydrate; Lodosyn; Carbidopa Hydrate; NSC-326223
EINECS	Contact for details

Quality Control

Our Carbidopa Monohydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines and current Good Manufacturing Practices (cGMP). Certificates of Analysis (COA) documenting results for assay, related substances, residual solvents, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	6.0% - 8.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.