Description

Rifampicin CAS NO 38776-75-9 is a semisynthetic, broad-spectrum antibiotic belonging to the ansamycin class, renowned for its potent bactericidal activity against mycobacteria. Its primary commercial value lies in its critical role as a first-line agent in the treatment of tuberculosis and other mycobacterial infections, forming the backbone of standard combination therapies. This active pharmaceutical ingredient (API) is essential for manufacturers in the global pharmaceutical industry producing anti-tuberculosis medications, as well as for research institutions developing novel antimicrobial formulations.

Application

• Pharmaceutical API: Primary use as the active ingredient in solid oral dosage forms (capsules, tablets) for the treatment of pulmonary and extrapulmonary tuberculosis.
• Combination Therapy: A key component in fixed-dose combination (FDC) anti-TB drugs, such as those with isoniazid, pyrazinamide, and ethambutol.
• Prophylaxis: Used in the prevention of meningococcal meningitis and Haemophilus influenzae type b infection in high-risk contacts.
• Veterinary Medicine: Employed in the treatment of certain bacterial infections in animals, under veterinary supervision.
• Research & Development: Serves as a critical reference standard and starting material in microbiological research and the development of new antibiotic agents.
• Leprosy Treatment: Used as part of multidrug therapy (MDT) regimens for the management of leprosy (Hansen's disease).

Basic Information

Product Name	Rifampicin
CAS No.	38776-75-9
Molecular Formula	C43H58N4O12
Molecular Weight	822.94 g/mol
Synonyms	Rifampin; Rifaldazine; 5,6,9,17,19,21-Hexahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[N-(4-methyl-1-piperazinyl)formimidoyl]-2,7-(epoxypentadeca[1,11,13]trienimino)naphtho[2,1-b]furan-1,11(2H)-dione 21-acetate; Rifamycin AMP; Rifamycin SV Derivative; Benemicin; Rifa; Tubocin
EINECS	254-169-6

Quality Control

Our Rifampicin is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical active ingredients. Quality is verified through comprehensive analytical testing, including HPLC for assay and related substances, microbial limits, and residual solvent analysis. We can supply material compliant with major pharmacopoeial standards such as USP, EP, and BP. A detailed Certificate of Analysis (COA) is provided with each batch to guarantee traceability, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen) for long-term stability. Keep the container tightly sealed to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	Reddish-brown crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	97.0% - 102.0% (on dried basis)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any individual impurity ≤ 1.0%
Heavy Metals	≤ 20 ppm
Microbial Enumeration	Meets Ph. Eur. 2.6.12 / USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.