Description

4-Fluorophenyl Chloroformate is a versatile and highly reactive chemical intermediate, primarily used as a key building block in organic synthesis. Its value lies in its ability to efficiently introduce the 4-fluorophenyloxycarbonyl group, facilitating the synthesis of complex molecules with precision. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly in the development of active pharmaceutical ingredients (APIs), advanced crop protection agents, and functional polymers.

Application

• Pharmaceutical Intermediate: A critical reagent for the synthesis of carbamate and carbonate derivatives used in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Employed in the production of advanced herbicides, fungicides, and insecticides that require the 4-fluorophenyl moiety.
• Polymer Chemistry: Used as a monomer or modifying agent to create specialty polymers with enhanced thermal or chemical resistance.
• Peptide & Protein Research: Serves as a protecting group reagent or coupling agent in solid-phase peptide synthesis (SPPS).
• Material Science: Facilitates the surface functionalization of materials for specialized coatings and composites.
• Chemical Research & Development: A valuable tool for medicinal chemists and process chemists in exploratory synthesis and route scouting.

Basic Information

Product Name	4-Fluorophenyl Chloroformate
CAS No.	38377-38-7
Molecular Formula	C7H4ClFO2
Molecular Weight	174.56 g/mol
Synonyms	p-Fluorophenyl Chloroformate; 4-Fluorophenyl Carbonochloridate; Chloroformic Acid 4-Fluorophenyl Ester; (4-Fluorophenoxy)carbonyl Chloride; F-Phenyl Chloroformate; 4-Fluorophenol Chloroformate; Carbonochloridic Acid, 4-Fluorophenyl Ester
EINECS	Contact for details

Quality Control

Our 4-Fluorophenyl Chloroformate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.