Description

4-o-[2-[Methyl(1-Methylethyl)Amino]-2-Oxoethyl]Rifamycin is a semi-synthetic derivative of the rifamycin class of antibiotics, specifically engineered for enhanced pharmacological properties. This compound is of significant commercial interest for its role as a key intermediate in the synthesis of advanced antibiotic formulations. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development of novel anti-tuberculosis and broad-spectrum antibacterial agents. Our supply ensures high purity and batch-to-batch consistency critical for pharmaceutical R&D and production.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of next-generation rifamycin-based antibiotics.
• Antibacterial Research: Used in preclinical and clinical research for developing new treatments against drug-resistant bacterial strains, particularly Mycobacterium tuberculosis.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a precursor in the manufacturing process of finished dosage forms.
• Biochemical Studies: Employed in studies investigating the mechanism of action of antibiotics that inhibit bacterial RNA polymerase.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	4-o-[2-[Methyl(1-Methylethyl)Amino]-2-Oxoethyl]Rifamycin
CAS No.	38128-77-7
Molecular Formula	C39H52N2O13
Molecular Weight	756.84 g/mol
Synonyms	Rifamycin Derivative; Rifamycin SV, 4-O-[2-[Methyl(1-methylethyl)amino]-2-oxoethyl]-; 4-Deoxy-3,4-[2-[N-isopropyl-N-methylcarbamoyl]ethylidene]rifamycin SV; Rifamycin SV IPM Ester; 4-O-(2-(N-Isopropyl-N-methylcarbamoyl)ethyl)rifamycin SV; 3-[[(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E,26E,28S)-21-Acetyloxy-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22,28-octamethyl-1-oxo-27-(oxolan-2-yl)-3,30-dioxa-24-azapentacyclo[23.3.1.14,7.02,7.013,18]triaconta-12,14,24,26,29-pentaen-11-yl]oxy]-2-methylbut-2-enoic acid; 4-O-[2-(N-Isopropyl-N-methylamino)-2-oxoethyl]rifamycin
EINECS	Contact for details

Quality Control

Our 4-o-[2-[Methyl(1-Methylethyl)Amino]-2-Oxoethyl]Rifamycin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure compliance with ICH guidelines for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to guarantee traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere packaging to maintain stability.

Specification

Item	Specification
Appearance	Orange-red to brownish-red powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.