Description

6-[α-Amino-α-(4-Hydroxyphenyl)Acetamido]Penicillanic Acid is a key pharmaceutical intermediate, specifically a penicillanic acid derivative, essential for the synthesis of advanced β-lactam antibiotics. Its primary value lies in enabling the production of semi-synthetic penicillins with enhanced properties, such as improved stability and spectrum of activity. This compound is critically needed by pharmaceutical manufacturers and research institutions engaged in the development and production of next-generation antibacterial agents.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: A crucial building block in the multi-step synthesis of semi-synthetic penicillin antibiotics.
• Antibacterial Research & Development: Serves as a core scaffold for medicinal chemists to develop novel β-lactam compounds with targeted efficacy.
• Pharmaceutical Intermediates Production: Used in the commercial-scale manufacturing of intermediates for amoxicillin and related antibiotic derivatives.
• Biochemical Studies: Employed in research to study the structure-activity relationships (SAR) of penicillin-class drugs and bacterial resistance mechanisms.

Basic Information

Product Name	6-[α-Amino-α-(4-Hydroxyphenyl)Acetamido]Penicillanic Acid
CAS No.	38083-36-2
Molecular Formula	C16H19N3O5S
Molecular Weight	365.40 g/mol
Synonyms	6-[[Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-[[(2R)-Amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Amoxicillin Intermediate; 6-APA Derivative; 6-ADHPA; D-(-)-α-Amino-p-hydroxybenzyl penicillinic acid
EINECS	Contact for details

Quality Control

Our 6-[α-Amino-α-(4-Hydroxyphenyl)Acetamido]Penicillanic Acid is produced under strict quality management systems. The product undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) are provided with each batch, detailing specifications for assay, related substances, and residual solvents. We support compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and potency. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.