Description

2,5-Difluorocinnamicacid is a high-purity fluorinated cinnamic acid derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the aromatic ring, which significantly influences the electronic properties, metabolic stability, and binding affinity of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, especially in kinase inhibitor and anti-inflammatory research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the difluoro motif enhances biological activity.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies.
• Organic Light-Emitting Diodes (OLEDs): Acts as a building block for electron-transport or emissive layer materials.
• Cross-Coupling Reactions: A valuable substrate in Suzuki, Heck, and other palladium-catalyzed coupling reactions to create complex biaryl structures.
• Chemical Research: Used in academic and industrial R&D for studying structure-activity relationships (SAR) and fluorine chemistry.

Basic Information

Product Name	2,5-Difluorocinnamicacid
CAS No.	37368-88-0
Molecular Formula	C9H6F2O2
Molecular Weight	184.14 g/mol
Synonyms	(2E)-3-(2,5-Difluorophenyl)acrylic acid; (E)-3-(2,5-Difluorophenyl)-2-propenoic acid; trans-2,5-Difluorocinnamic acid; 2,5-Difluorocinnameic acid; 2,5-DFCA; 2,5-Difluorobenzeneacrylic acid; β-(2,5-Difluorophenyl)acrylic acid
EINECS	Contact for details

Quality Control

Our 2,5-Difluorocinnamicacid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Custom purity grades and analytical packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	158 - 162 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.