Description

Capreomycin Ia is a cyclic peptide antibiotic belonging to the capreomycin complex, primarily isolated from *Streptomyces capreolus*. This compound is a critical secondary metabolite valued for its specific antibacterial activity against *Mycobacterium tuberculosis*. It is essential for pharmaceutical research and development, particularly in the formulation of anti-tuberculosis drugs and the study of antibiotic mechanisms. Key industries requiring this high-purity reference standard include pharmaceutical manufacturing, academic research, and clinical diagnostics.

Application

• Pharmaceutical Reference Standard: Serves as a primary chemical reference material (CRM) for quality control and assay calibration in anti-tuberculosis drug manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the synthesis and formulation of second-line injectable treatments for multidrug-resistant tuberculosis (MDR-TB).
• Microbiological Research: Employed in in-vitro studies to investigate its mechanism of action, bacterial resistance patterns, and synergistic effects with other antibiotics.
• Analytical Method Development: A critical component for developing and validating HPLC, LC-MS, and other chromatographic methods in quality control laboratories.
• Biochemical Studies: Used to study protein synthesis inhibition in bacteria, specifically targeting the ribosomal subunit.

Basic Information

Product Name	Capreomycin Ia
CAS No.	37280-35-6
Molecular Formula	C25H44N14O8
Molecular Weight	668.71 g/mol
Synonyms	Capreomycin IA; Capreomycin I; Capreomycin A; Capastat component IA; (1R)-4,6-Diamino-N-[[(1S)-5-amino-1-[[(4S,7R,10S,13R,16S,19R,22S,25S,28S,31R,34S)-7,16,22,31-tetramethyl-4,10,13,19,25,28-hexaoxo-34-(3-phenylpropanoylamino)-2,5,8,11,14,17,20,23,26,29,32-undecaazatricyclo[29.3.0.03,9]tetratriacontan-1-yl]amino]-1,5-dioxopentan-2-yl]carbamoyl]-1-(carbamoylamino)-3-hydroxy-1,2,3,4-tetrahydrocyclopenta[c]pyrrole-5-carboxamide; Antibiotic A 16686; Antibiotic A-16686; Antibiotic A16686
EINECS	Contact for details

Quality Control

Our Capreomycin Ia is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and potency, aligning with standards relevant for pharmaceutical reference materials. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological tests is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Microbial Enumeration	Meets Ph. Eur. 2.6.12 / USP <61> requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.