Description

Poly(2'-Deoxyguanyl-2'-Deoxycytidylic Acid) So-Sa., 250 Ug* is a defined-sequence oligonucleotide, specifically a poly(dG-dC) polymer, widely utilized as a critical reagent in molecular biology and biochemical research. This compound matters for its role as a standard and template in nucleic acid hybridization studies, polymerase chain reaction (PCR) optimization, and investigations into DNA structure and protein-DNA interactions. Life science researchers, diagnostic kit developers, and pharmaceutical R&D teams need this high-purity synthetic DNA for applications requiring precise and reproducible nucleic acid behavior.

Application

• Molecular Biology Research: Used as a standard or control in hybridization experiments, Southern blotting, and microarray validation.
• PCR & qPCR Optimization: Serves as a non-specific template or competitor DNA for optimizing primer annealing conditions and assay sensitivity.
• Biophysical Studies: Employed in research on DNA duplex stability, Z-DNA formation, and interactions with intercalating agents or proteins.
• Diagnostic Assay Development: Acts as a synthetic target or control material in the development of nucleic acid-based diagnostic tests.
• Pharmaceutical Screening: Used in high-throughput screening assays to identify compounds that bind to or alter double-stranded DNA structures.
• Teaching & Reference Standard: Provides a well-characterized DNA polymer for educational laboratories and as a quality control reference.

Basic Information

Product Name	Poly(2'-Deoxyguanyl-2'-Deoxycytidylic Acid) So-Sa., 250 Ug*
CAS No.	36786-90-0
Molecular Formula	(C19H23N7O11P2)n
Molecular Weight	~ (Monomer: 625.37 g/mol). Polymer molecular weight varies by chain length (n).
Synonyms	Poly(dG-dC); Poly(deoxyguanylic-deoxycytidylic acid); Poly(dG-dC) homopolymer; Alternating dG-dC copolymer; Poly(dG-dC):poly(dG-dC); Synthetic DNA polymer; Oligonucleotide dG-dC polymer; Poly(deoxyguanylate-deoxycytidylate)
EINECS	Contact for details

Quality Control

Our Poly(2'-Deoxyguanyl-2'-Deoxycytidylic Acid) is manufactured and tested to meet the stringent requirements of research applications. Each batch undergoes rigorous quality testing, including assessment of purity, sequence integrity, and absence of nucleases. Certificates of Analysis (COA) detailing specifications such as HPLC purity, absorbance ratios (A260/A280), and endotoxin levels are available upon request to ensure traceability and compliance with your experimental protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake. Aliquot into smaller volumes after initial thawing to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Oligonucleotide content)
Absorbance Ratio (A260/A280)	1.8 - 2.0
Molecular Weight Distribution	Specified by chain length (n) or base pairs
Endotoxin Level	< 10 EU/mg (or per customer requirement)
Solubility	Soluble in TE buffer or nuclease-free water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.