Description

Mantabegron CAS NO 36144-08-8 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) of significant commercial interest. This compound is a key building block in the synthesis of advanced therapeutic agents, particularly in the urology and cardiovascular fields. It is essential for pharmaceutical manufacturers and research institutions engaged in the development and production of novel drug formulations.

Application

• Pharmaceutical Intermediate: Primary use as a critical precursor in the synthesis of β-3 adrenergic receptor agonists.
• Active Pharmaceutical Ingredient (API): Serves as the core active component in the manufacture of finished dosage forms for clinical use.
• Research & Development: Utilized in biochemical and pharmacological research for studying receptor mechanisms and developing new therapeutic candidates.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and commercial production.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.

Basic Information

Product Name	Mantabegron
CAS No.	36144-08-8
Molecular Formula	C19H24N2O3
Molecular Weight	328.41 g/mol
Synonyms	Mirabegron Intermediate; (R)-2-(2-Aminothiazol-4-yl)-4'-[2-[(2-hydroxy-2-phenylethyl)amino]ethyl]acetanilide; β-3 Adrenergic Receptor Agonist Intermediate; 4-[2-[[(2R)-2-Hydroxy-2-phenylethyl]amino]ethyl]-N-(4-methyl-1,3-thiazol-2-yl)benzamide; Solabegron Intermediate; Vibegron Intermediate; YM178 Intermediate
EINECS	Contact for details

Quality Control

Our Mantabegron is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments. Production can adhere to cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5%
Any single impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.