Description

4-Thia-1-Azabicyclo3.2.0Heptane-2-Carboxylic Acid, 6-Methoxy-3,3-Dimethyl-7-Oxo-6-(Phenoxyacetyl)Amino-, (2S,5R,6S)- is a high-purity pharmaceutical intermediate of significant commercial importance. This compound is a key building block in the synthesis of advanced β-lactam antibiotics, valued for its defined stereochemistry and structural integrity. It is primarily required by manufacturers in the active pharmaceutical ingredient (API) and fine chemical sectors for research, development, and production.

Application

• Synthesis of β-Lactam Antibiotics: A crucial intermediate in the production of penicillin and cephalosporin derivatives.
• Active Pharmaceutical Ingredient (API) Manufacturing: Used in the chemical synthesis of specific antibiotic APIs requiring the (2S,5R,6S) stereochemistry.
• Pharmaceutical Research & Development: Serves as a key chiral synthon in medicinal chemistry for developing new antimicrobial agents.
• Fine Chemical Production: Employed in custom synthesis and contract manufacturing for specialized chemical entities.
• Process Chemistry Optimization: Used in scaling up and optimizing synthetic routes for antibiotic production.
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control in pharmaceutical labs.

Basic Information

Product Name	4-Thia-1-Azabicyclo3.2.0Heptane-2-Carboxylic Acid, 6-Methoxy-3,3-Dimethyl-7-Oxo-6-(Phenoxyacetyl)Amino-, (2S,5R,6S)-
CAS No.	35353-34-5
Molecular Formula	C18H22N2O6S
Molecular Weight	394.44 g/mol
Synonyms	(2S,5R,6S)-6-Methoxy-3,3-dimethyl-7-oxo-6-[(phenoxyacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6-Methoxy-3,3-dimethyl-7-oxo-6-(phenoxyacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Phenoxymethylpenicillinic Acid Derivative; 6-APA Phenoxyacetyl Ester; D-(-)-α-Phenoxypropionamidopenicillanic Acid Precursor
EINECS	Contact for details

Quality Control

Our 4-Thia-1-Azabicyclo3.2.0Heptane-2-Carboxylic Acid, 6-Methoxy-3,3-Dimethyl-7-Oxo-6-(Phenoxyacetyl)Amino-, (2S,5R,6S)- is manufactured under strict quality systems suitable for pharmaceutical applications. Production adheres to cGMP (current Good Manufacturing Practice) guidelines, and the material is subjected to rigorous analytical testing including HPLC, NMR, and chiral purity analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to ensure compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (2S,5R,6S) isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.