Description

p-Ethylthymidylyl-(3'-5')-Thymidine is a chemically modified dinucleotide, specifically a thymidine dimer with an ethyl group substitution. This compound is a critical building block and research tool in the fields of oligonucleotide synthesis and nucleic acid chemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, diagnostics, and advanced molecular biology applications.

Application

• Oligonucleotide Synthesis: Serves as a key phosphoramidite or solid-phase synthesis intermediate for creating modified DNA/RNA strands.
• Antisense & siRNA Research: Used in the development of therapeutic oligonucleotides with enhanced stability and binding properties.
• Probe & Primer Development: Acts as a component in the design of specialized hybridization probes and primers for sensitive diagnostic assays.
• Structural Studies: Employed in NMR and X-ray crystallography to study nucleic acid conformation and interactions.
• Enzyme Substrate & Inhibitor Studies: Utilized to investigate the mechanism and specificity of nucleases, polymerases, and other nucleic acid-processing enzymes.
• Pharmaceutical Intermediate: A potential precursor in the synthesis of nucleoside-based antiviral or anticancer prodrugs.

Basic Information

Product Name	p-Ethylthymidylyl-(3'-5')-Thymidine
CAS No.	35002-96-1
Molecular Formula	C23H30N4O13P
Molecular Weight	601.48 g/mol
Synonyms	Thymidylyl-(3'→5')-thymidine, 5'-ethyl ester; 5'-O-Ethylthymidylyl-(3'-5')-thymidine; dTpdT ethyl ester; ET-T dimer; Dinucleotide T-T ethyl phosphate; 2'-Deoxythymidylyl-(3'-5')-2'-deoxythymidine 5'-ethyl phosphate
EINECS	Contact for details

Quality Control

Every batch of p-Ethylthymidylyl-(3'-5')-Thymidine is produced and tested under strict quality management protocols to ensure consistency and reliability for research applications. Our products undergo rigorous analytical testing, including HPLC for purity and identity confirmation via mass spectrometry. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.