Description

(20S)-20-Hydroxy-3,6-Dioxo-5α-Pregnan-18-Oic Acid γ-Lactone is a high-purity steroid derivative and a key synthetic intermediate in advanced pharmaceutical research and development. Its value lies in its specific stereochemistry and functional groups, which make it a crucial building block for synthesizing complex bioactive molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries working on novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel steroid-based drugs and active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard or starting material in metabolic pathway studies and steroid hormone research.
• Process Chemistry: Serves as a key chiral building block for developing scalable, cost-effective synthetic routes for complex target molecules.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for the production of client-specific advanced intermediates.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and medicinal chemistry projects.

Basic Information

Product Name	(20S)-20-Hydroxy-3,6-Dioxo-5α-Pregnan-18-Oic Acid γ-Lactone
CAS No.	34137-21-8
Molecular Formula	C21H28O5
Molecular Weight	360.45 g/mol
Synonyms	20-Hydroxy-3,6-dioxo-5α-pregnan-18-oic acid γ-lactone; 18,20-Lactone of 20-hydroxy-3,6-dioxo-5α-pregnan-18-oic acid; 5α-Pregnan-18-oic acid, 20-hydroxy-3,6-dioxo-, γ-lactone, (20S)-; 20(S)-Hydroxy-3,6-dioxopregn-18-oic acid γ-lactone; 18→20 Lactone of 20-Hydroxy-3,6-dioxo-5α-pregnan-18-oic Acid; (20S)-20-Hydroxy-3,6-dioxopregnan-18-oic acid γ-lactone
EINECS	Contact for details

Quality Control

Our (20S)-20-Hydroxy-3,6-Dioxo-5α-Pregnan-18-Oic Acid γ-Lactone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (20S-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.