Description

Benzoicacid, 3-Chloro-4-(Fluorosulfonyl)- is a high-value, multi-functional aromatic intermediate with a unique sulfonyl fluoride moiety. This compound matters for its role as a versatile building block in advanced synthesis, enabling the introduction of both halogen and fluorosulfonyl groups into target molecules. It is primarily needed by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, protease inhibitors, and other bioactive molecules.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides that require sulfonyl fluoride chemistry for enhanced activity and selectivity.
• Chemical Biology & Proteomics: Serves as a reactive handle in activity-based protein profiling (ABPP) and the development of covalent enzyme inhibitors due to the sulfonyl fluoride group's reactivity with serine hydrolases.
• Material Science Precursor: Employed in the synthesis of specialized polymers, liquid crystals, and advanced materials where the introduction of specific aromatic and fluorine-containing units is required.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.

Basic Information

Product Name	Benzoicacid, 3-Chloro-4-(Fluorosulfonyl)-
CAS No.	33866-05-6
Molecular Formula	C7H4ClFO4S
Molecular Weight	238.62 g/mol
Synonyms	3-Chloro-4-(fluorosulfonyl)benzoic acid; 4-(Fluorosulfonyl)-3-chlorobenzoic acid; 3-Chloro-4-fluorosulfonylbenzoic acid; Benzoic acid, 3-chloro-4-(fluorosulfonyl)-; 33866-05-6; 3-Chloro-4-fluorosulfonyl-benzoic acid; 3-Chloro-4-fluorosulfonyl benzoic acid; 3-Chloro-4-(fluorosulfonyl)benzoic acid (CAS 33866-05-6)
EINECS	Contact for details

Quality Control

Our Benzoicacid, 3-Chloro-4-(Fluorosulfonyl)- is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.